From NH Agricultural Station: Thanks in part to a newly awarded grant from the U.S. Geological Survey, researchers at UNH’s NH Veterinary Diagnostic Lab (NHVDL) and the Hubbard Center for Genome Studies (HCGS) — along with partners at UNH’s Research Computing Center, the University of Vermont and the University of Maine — are working to establish baseline data on where different ticks are found, their numbers, and what pathogens they may carry across diverse vertebrate hosts.
The effort will inform future epidemiological studies on the spread of tick-transmitted diseases allow state agencies to target education and control efforts in high-risk areas to help mitigate the growing health threats posed by ticks and tick-borne illnesses to wildlife, pets, livestock and people in northern New England.
“In the past, tick-born illnesses — and even ticks themselves — were not a large concern in this region for clinical practices,” said David Needle, a senior veterinary pathologist and pathology section chief with the NHVDL and a clinical associate professor in the department of molecular, cellular and biomedical sciences.
“Today, veterinarians are engulfed in work related to the increased burden of ticks and tick-borne diseases which infect domesticated and wild animals in the region,” he added. “Tick prevention is now a vital part of veterinary care for companion animals and livestock, and vaccination against Lyme disease is amongst the most common vaccines administered to dogs.”
The two-year project, which Needle is spearheading, will use genomic sequencing to screen ticks found on ticks from deer, moose, bears, furbearers (a group of mammals that includes racoons, skunk, fox, coyote, beaver and fishers), and birds and bats across northern New England for both known and new microbial pathogens.
According to W. Kelley Thomas, director of the HCGS, researchers from HCGS and from the new Collaborative Core Wet Lab will extract DNA and RNA from individual ticks, as well as from their blood meal (the blood they take from host animals) and the microbes found in the ticks and within their blood meal.
“That DNA will be sequenced to understand the diversity of the ticks, their hosts and to identify known and unknown potential pathogens,” added Thomas, a professor of molecular, cellular and biomedical sciences at UNH.
Tick-borne diseases have been escalating in New Hampshire over the past two decades. According to the New Hampshire Department of Health and Human Services, cases of Lyme disease in the state rose from 262 (total) in 2002 to 1710 (confirmed and probable) in 2019. Reported cases of babesiosis (a microscopic tick-borne parasite) has also spiked in the U.S., rising from 1,126 in 2011 to 2,074 cases by 2015. Additionally, U.S. medical costs associated with tick-borne diseases are also substantial, with Lyme disease alone resulting in anywhere between $712 million and $1.3 billion in annual treatment costs, according to a 2015 report by Johns Hopkins.
Compounding these trends, new tick species such as the invasive lone star and Asian longhorned ticks have either recently been discovered in or have expanded their range closer to New Hampshire and northern New England in general. These exotic ticks can transmit deadly diseases like ehrlichiosis and pose serious threats to wildlife, pets, livestock and public health, which is why, according to Needle, more support for continual monitoring of tick populations and pathogens are critical to assess emerging risks, guide management policies and protect New Hampshire from the escalating impacts of ticks and tick-borne diseases.
“Ultimately, the data we generate can help inform public health efforts,” he added, “and it will serve as a key warning system to pet owners, livestock producers and the general populace —and just as importantly to the human and veterinary medicine practitioners responsible for safeguarding the health of these populations and their animals.”
This project is being conducted in collaboration with the Entomology Research Laboratory at University of Vermont, which is focused on studying fungal colonization in ticks to identify possible biocontrol methods, as well as the Tick Lab at the University of Maine Extension Diagnostic and Research Laboratory. The UNH Research Computing Center will also help in managing the data and making it public.
Funding:
This material is based upon work supported by the U.S. Geological Survey.
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